Dr. Alberto Laffranchi: Tumorpathogenese – Wachstum, Gene, Rezeptoren und Umwelt
Cancer medicine is increasingly moving toward a new era of personalized diagnostics and therapeutics that aggressively embraces integrative approaches (De Palma and Hanahan, 2012). Looking forward, combinatorial strategies will target not only cancer cell-intrinsic pathways, but also cancer cell-extrinsic cells, pathways, and mediators at play in the TME. As the strategic goal of deciphering the roles of the TME in primary and metastatic tumor locales progresses, new discoveries can be envisioned to produce innovative multitargeting strategies that will be able to more thoroughly extinguish primary and metastatic disease, while circumventing elucidated adaptive resistance mechanisms to such therapies, profoundly altering he prognosis for many forms of human cancer (De Palma and Hanahan, 2012). The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic- They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Underlying these hallmarks is genome instability, which generates the genetic diversity that expedites their acquisition and inflammation, which fosters multiple hallmark functions. Conceptual progress in the last decade has added two emerging hallmarks of potential generality to this list – reprogramming of energy metabolism and evading immune destruction. In addition to cancer cells, tumors exhibit another dimension of complexity: they contain a repertoire of recruited, ostensibly normal cells that contribute to the acquisition of hallmark traits by creating the „tumor microenvironment.“ Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer (Douglas Hanahan 2013).
Über Dr. Alberto Laffranchi
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[TAB:Hinweis]Der Referent spricht englisch und wird nicht übersetzt.